With the development of photochemical synthesis reactions in the field of organic synthesis, flow photochemical synthesis reactions have become an effective alternative to traditional methods for the synthesis of drugs and fine chemicals due to their advantages such as mild reaction conditions, safety, high light absorption efficiency, high mass and heat transfer efficiency, and ease of scaling up production.
Perfectlight Technology introduces the PLR-SMCR1000 multiphase microchannel reaction system, providing a platform for studying continuous-flow photochemical synthesis methodologies, suitable for homogeneous photochemical synthesis reactions. The introduced Taylor① fluidic structure simultaneously meets the requirements of gas/liquid and liquid/liquid heterogeneous synthesis reactions.
▲ Especially Suitable ● Moderately Suitable ○ Applicable
▲ Photochemical organic synthesis
▲ Photochemical fine chemical synthesis
▲ Feasibility verification of kettle reaction amplification
▲ Pilot production of tubular photochemical synthesis reactions
▲ Thermodynamic flow chemical synthesis
▲ Study of Taylor flow two-phase mass transfer behavior
Ring addition reactions, C-C coupling reactions, C-N coupling reactions, C-O coupling reactions, halogenation/dehalogenation reactions, decarboxylation/carboxylation reactions, addition reactions to double bonds, three-membered heterocycle ring-opening reactions, asymmetric synthesis, and more.
● Continuous flow microreaction channels to enhance reaction performance;
The PLR-SMCR1000 multiphase microchannel reaction system uses single-layer, highly transparent millimeter-scale (0.1~10 mm) continuous-flow microreaction pipelines as photochemical reaction vessels. It reduces the light transmittance depth required for the reaction from centimeters in kettle reactions to a micrometer scale, effectively increasing the light absorption efficiency of photochemical reaction substrates, and significantly shortening the reaction time.
The continuous flow microreaction pipes of the PLR-SMCR1000 multiphase microchannel reaction system have a good overall heat transfer coefficient of 250 kW/(m3·K), which is several times higher than that of traditional kettle reactions. This effectively reduces the probability of local side reactions and stabilizes the stability, repeatability, and yield of continuous-flow photochemical reactions.
The continuous flow microreaction pipes of the PLR-SMCR1000 multiphase microchannel reaction system have a pressure resistance of ≥0.6 MPa and are combined with a flow system to improve the safety of gas participation or generation in the reaction.
● Multiphase Taylor fluid for heterogeneous reactions;
The PLR-SMCR1000 multiphase microchannel reaction system comes with three liquid-phase reaction channels and one gas-phase reaction channel. The gas-phase route can be used for reactions involving gases such as CO₂, Cl₂, and O₂.
For gas/liquid and liquid/liquid heterogeneous reactions, the multiphase continuous-flow photochemical reaction system introduces gas-liquid and liquid-liquid Taylor fluids, which can promote the mixing rate inside the photochemical reaction phase, continually refresh the two-phase contact interface, and effectively increase the reaction rate at the interface of continuous-flow photochemical reactions.
● Flexible configuration for easy control of reaction conditions;
The PLR-SMCR1000 multiphase microchannel reaction system offers two different reaction volumes of 5 mL and 10 mL in the continuous flow microreaction pipes, with a recommended liquid flow rate range of 0.5~8.0 mL/min and a recommended gas flow rate range of 0~20 mL/min. The adjustable flow velocity for continuous fluids can achieve a residence time of 0.625~20 minutes, which can be controlled to adjust the progress of multi-substituted reactions, thus optimizing the yield of target substituted products.
The PLR-SMCR1000 multiphase microchannel reaction system can be used with high-sealing material bottles and substrate collection bottles and can be used in conjunction with PLS-MAC1005 Atmosphere Controller for inert gas protection of substrates participating in photochemical reactions and the products of the reactions.
The PLR-SMCR1000 multiphase microchannel reaction system has strong scalability and can connect multiple continuous flow microreaction pipes in series to form a multi-channel microreaction pipeline, realizing the continuous multistage synthesis process of photochemical organic reactions, especially suitable for continuous photochemical processes with unstable intermediate product generation.
● Real-time analysis to facilitate intelligent optimization and collection;
The PLR-SMCR1000 multiphase microchannel reaction system can be used in conjunction with fiber optic spectrometers and other detection equipment to monitor the absorption spectra of the effluent of photochemical reactions in real-time. This enables real-time determination of substrate conversion rates and product generation rates, facilitating rapid optimization of reaction conditions that affect photochemical synthesis, such as the pre-mixing sequence, light intensity, flow rate, and reaction temperature. It can also intelligently determine the waste liquid discharge time and reaction substrate collection time, thereby improving the purity of collected products.
● Customized LED light sources to excite "tailor-made" photochemical reactions;
The PLR-SMCR1000 multiphase microchannel reaction system is equipped with LED light sources with selectable output wavelengths in the range of 255~760 nm, allowing precise adjustment and acquisition of the optimal wavelength for photochemical reactions. The LED light source's electrical power can be adjusted from 10~120 W, making it suitable for photochemical synthesis experiments with low light power.
Selectable LED wavelengths:
① Ultraviolet region - suitable for substrate-initiated free radical chain reactions
λ=255, 275 nm
② Visible light region - to achieve visible light excitation of catalyst-initiated free radical reactions while reducing side reactions initiated by the substrate, improving reaction selectivity
λ=365, 385, 405, 410, 420, 435, 445, 450, 460, 475, 485, 505, 520, 525, 535, 550, 575, 590, 595, 620, 625, 630, 655, 685, 700, 730, 760, 770 nm
③ Visible light region - simulating the reaction suitability under sunlight
780≥λ≥380 nm
For the most common blue and green light absorption regions of photocatalysts, there are ten absorption wavelengths available: 450 nm, 460 nm, 475 nm, 485 nm, 505 nm, 520 nm, 525 nm, 535 nm, 550 nm, and 575 nm. These can be combined and precisely controlled to obtain the best light wavelength.
● Precise temperature control with water cooling for adjustable reaction rates;
In most photosynthesis experiments, controlling the reaction temperature can adjust the reaction rate.
For reactions with slow rates at room temperature, the reaction temperature can be raised to 80°C.
For reactions with high free radical activity and many side reactions, precise control at -10°C can reduce free radical activity, reduce side reactions, and increase the yield of the main product. This is especially suitable for temperature-sensitive asymmetric catalytic reactions, as low-temperature photochemical reactions can effectively reduce chiral inversion of products, increasing product chiral selectivity.
For pilot/small-scale reaction systems or custom production-level devices, please call 400-1161-365.
①Taylor flow is a wide-ranging operational mode in gas-liquid/liquid-liquid two-phase flow, composed of a series of gas bubbles and liquid bullets that appear periodically in alternating order.
